Biofunctional Engineering


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Biofunctional Engineering



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Protein diffusion in a cell

We are elucidating the mechanisms by which the functions of cells and tissues adapt to mechanical environments on the basis of biomechanics. We are also trying to clarify the mechanism and micro- and nanoscopic biotransport. Macroscopic biotransport can be often be analyzed by using a differential equation to model physical phenomena. However, biotransport at much smaller scales (the micro-and nano-scales) is more difficult to model in physical detail. Clarification of the mechanisms of such micro- and nanoscale biotransport will be useful not only in improving our understanding of the mechanisms of disease and the maintenance of stable biological functions, but also for the development of clinical applications such as tissue engineering. The following are examples of the studies that have been performed.


Professor Susumu Kudo
Associate Professor Toshihiro Sera
Assistant Professor Kazuhiro Nakashima

The Main Research Topics

  • Effect of ambient temperature on finger skin blood flow
  • Effect of shear stress on functions of endothelial cells
  • Effect of shear stress on macromolecule permeability across endothelial cells
  • Effect of flow load on hepatic function in co-culture of hepatocytes and endothelial cells
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